Her first destination was Southampton, England, although her home port was Barcelona until 23 October 2016 when she crossed the Atlantic. After a construction time of 32 months, the ship first set sail on from the STX France docks in Saint-Nazaire, viewed by some 70,000 people. The vessel was floated out on 19 June 2015, began her first sea trials on 10 March 2016, and was delivered to Royal Caribbean on. Harmony of the Seas is named after the Harmony module on the International Space Station. The success of the first two Oasis-class ships led Royal Caribbean Cruises to order a third ship of the type in December 2012. History Harmony of the Seas as she appeared when being built at STX yards in France In length, however, Harmony of the Seas is the longest cruise ship in the world. With a gross tonnage of 226,963 GT, she is the third largest passenger ship in the world, larger than her older sisters Oasis of the Seas and Allure of the Seas, but surpassed by her newer sisters Symphony of the Seas and Wonder of the Seas. Harmony of the Seas is an Oasis-class cruise ship built by STX France at the Chantiers de l'Atlantique shipyard in Saint-Nazaire, France, for Royal Caribbean International. CADTH is not liable for any loss or damages resulting from use of the information in the report.Approximately 120,000 t (132,000 short tons) While CADTH has taken care in the preparation of the report to ensure that its contents are accurate, complete and up to date, CADTH does not make any guarantee to that effect. Readers are also cautioned that a lack of good quality evidence does not necessarily mean a lack of effectiveness particularly in the case of new and emerging health technologies, for which little information can be found, but which may in future prove to be effective. The information included in this response is not intended to replace professional medical advice, nor should it be construed as a recommendation for or against the use of a particular health technology. Rapid responses should be considered along with other types of information and health care considerations. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The purpose of this report is to provide information on the cost-effectiveness of non-invasive pre-natal testing and to describe evidence-based guidelines for its use.ĭisclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. At present there is some uncertainty around the incorporation of NIPT into current strategies for prenatal screening and diagnosis. Among other factors, cost implications for introducing this new technology in clinical practice will need to be considered. A Canadian economic study reported a cost range of C$600 to C$800 for NIPT. The cost of NIPT ranges from US$800 to US$2000 in the USA and from US$500 to US$1500 elsewhere. Hence, there is no risk of fetal DNA persisting from one pregnancy to the next and confounding test results. The half-life of cffDNA is short and clears from maternal circulation soon after delivery. Approximately 10% to 15% of the cell free deoxyribonucleic acid (DNA) in maternal blood comprises of cffDNA. NIPT has been used for assessing abnormalities such as trisomy 21, trisomy 18, and trisomy 13. NIPT has a false positive rate of about 0.2% and detection rate of about 98% for Down syndrome. This method, known as non-invasive prenatal testing (NIPT), is a molecular approach for assessing fetal aneuploidy using cell-free fetal deoxyribonucleic acid (cffDNA) from the plasma of pregnant women. Recently, a novel prenatal testing method has become available. Recent advances in genomic sequencing and bioinformatics have led to development of noninvasive detection methods with detection rates approaching those obtained with amniocentesis and chorionic villus sampling (CVS).
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